Important people in my life

You do not need a Missouri driver license if: You are a member of the armed forces and you have a valid driver license from your home state. REQUIREMENTS TO OBTAIN A LICENSE OR PERMIT Depending on your age, whether ...

Fraud risk management

The original guide to good practice was based on the work of CIMA's Fraud and Risk Management Working Group that was established as part of the Institute's response to the problem of fraud. The legal defi nition varies from country ...

tp53 mutations in acute myeloid leukemia: still a daunting challenge?

Interestingly, despite variants in TP53 usually determined a loss-of-function of the tumor-suppressor activity of the protein, the R282 site was found to belong to the gain-of function mutations. In AML, TP53 mutations correlate with low-rate of response to standard chemotherapy ...

Targeting the endothelium to achieve cardioprotection

The endothelium is a monolayer of cells that covers the interior of every major and minor vessel and is the first line of contact between the lumen and other tissues. Regarding problems with translation, Heusch has previously highlighted the importance ...

Collective trauma and the social construction of meaning

It suggests that the tragedy is represented in the collective memory of the group, and like all forms of memory it comprises not only a reproduction of the events, but also an ongoing reconstruction of the trauma in an attempt ...

Eph-ephrin signaling mediates cross-talk within the bone microenvironment

The present review describes the erythropoietin-producing human hepatocellular receptor tyrosine kinase family and the Eph receptor interacting protein ligands that are expressed by stromal, hematopoietic, and vascular populations and the function of Eph/ephrin molecules within the bone microenvironment. The structure ...

Gaming science: the “gamification” of scientific thinking

As developmental psychologists, we are interested in the factors that influence the origins and growth of scientific thinking across the lifespan, from the child in a science classroom to the scientifically literate adult or practicing scientist. We suggest that one ...

Regulation of intestinal inflammation by dietary fats

Traditionally, dietary saturated FAs have been associated with cardiovascular disease; however, the effect of saturation on biology depends on the length of the FA carbon chain and the location and spatial effect of the hydrogen saturation within the carbon chain. ...

Heat stress impacts immune status in cows across the life cycle

One of the most effective indicators of the potential for heat stress, therefore, is the temperature-humidity index, which accounts for the impact of rising humidity diminishing the capacity for heat loss. The objective of this paper is to review the ...

The p2x7 receptor in osteoarthritis

Therefore, the occurrence and development of OA can be ascribed to the state and the catabolism balance of chondrocytes and cartilage. We explain the structure and function and the inhibitory effect of P2X7R and emphasize the correlation and intersection between ...

Serotonin and the regulation of mammalian energy balance

Altogether, a number of features of the obesity syndrome in 5HT2CR knockout mice resemble common forms of human obesity: chronic hyperphagia, lack of primary perturbations of metabolic rate, lack of primary perturbations of the regulation of hormones implicated in energy ...

Goals in nutrition science 2020-2025

The efficiency of functional food depends on the processes of digestion, absorption, metabolization of the ingested molecules and bioavailability in body fluids, cells, and tissues. Finally, nutritional and antioxidant intake of subjects should consider the effect of different cooking procedures ...

Educational fmri: from the lab to the classroom

A comprehensive list of all available strategies and practices in the current literature is beyond the scope of this review: our goal is to highlight that many ingenious solutions have been proposed in the literature, and that the field is ...

Does rubella cause autism: a 2015 reappraisal?

In a follow-up study of 205 of the original children at the ages of 8 9 years old, including 17 of the initial 18 with autism, she then diagnosed an additional 4 cases. The strongest argument against a spurious association ...

Microvascular alterations in alzheimer’s disease

In contrast to the AH, some studies suggest A is not the sole cause of AD. A counterargument in support of the AH is A deposition may be an early event that initiates AD pathology and cognitive decline.

Challenges and prospects in ocean circulation models

At present only the ACCESS and the IPSL-CM6 have implemented and plan operational use in CMIP6 of the new TEOS-10 equation of state with the exception of the preformed salinity. Thus, numerical and parameterization improvements will continue to define the ...

Impact of methamphetamine on infection and immunity

The sharing of drug paraphernalia combined with METH's perceived enhancement of sexual pleasure and the association of its use with unsafe sexual practices greatly increases the likelihood of the acquisition of human immunodeficiency virus and other infectious diseases. The use ...

Er-pm contact sites – snaring actors in emerging functions

The first insights only arrived in the 1990s, with observations suggesting that phosphoserine-derivatives in the mitochondrial membranes are synthesised by the ER, and that contact between the organelles was involved in lipid transfer. ER-PM MCSs in the axons and dendrites ...

Evolutionary mismatch in mating

Pollet and Saxton empirically examined the diversity of samples described in papers published in the 2015 2016 volumes of Evolution and Human Behavior and Evolutionary Psychology, two of the leading journals that publish research on human behavior and psychology from ...

Social touch in human–computer interaction

The sense of touch is the earliest sense to develop in a human embryo and is critical for mammals' early social development and to grow up healthily. The importance of touch as a modality in social communication is highlighted ...

Recent advances in camel immunology

In addition to their economic importance as domestic food animals in many regions of the world including the Middle East, different parts of Africa, and most regions of Asia, camels are also found in circus or zoological collections in the ...

Membrane rafts: portals for viral entry

The composition and properties of DRMs are dependent on the nature and concentration of the detergent, as well as the temperature and time of solubilization. In this way, the entry and signaling machinery of the virus is concentrated in membrane ...

Nurses’ workplace job satisfaction: implication for retention strategies essay

TABLE OF CONTENTSPAGEABSTRACTiiLIST OF TABLESvLIST OF FIGURESviCHAPTER IIntroduction1Background of the Study4Statement of the Problem7Purpose of the Study8Research Questions8Nature of the Study9Significance of the Study9Definition of Terms10Assumptions and Limitations10CHAPTER II REVIEW OF LITERATUREThe Current Nursing Shortage11Job Dissatisfaction Factors Causing Nurses to ...

Brain-machine interfaces to assist the blind

Such individuals became sources of inspiration for Denis Diderot in the writing of his 1749 essay The Letter on the Blind for the Benefit of Those Who See, where he lauded the abilities of blind people. At the start of ...

Is it possible to predict the future in first-episode psychosis?

Clinical insight changes over time in FEP, and likewise its correlation with symptoms and psychosocial functioning is not consistent in the early course of illness and the later course of illness. In clinical high-risk patients, elevated cortisol predicted transitioning to ...

Phenotyping for drought tolerance of crops in the genomics era

In agriculture, the term " drought" refers to a condition in which the amount of water available through rainfall and/or irrigation is insufficient to meet the transpiration needs of the crop. A classical formula that highlights the critical role of ...

pseudomonas aeruginosa: resistance to the max

This review provides an overview of antimicrobial resistance in P.aeruginosa that is acquired, either via mutation of endogenous genes or via acquisition of exogenous resistance genes.-Lactams, including penicillins, cephalosporins, carbapenems, and monobactams are commonly used in the treatment of P.aeruginosa ...

Key genetic parameters for population management

The relevant genetic parameters are the average breeding value for total merit, the genetic diversity of the population, and the genome equivalent that is contributed by the breed to the genetic diversity of the species. For example, the genome equivalent ...

Transcriptomics of biostimulation of plants under abiotic stress

Currently, the advancement of omics sciences through the development of genome sequencing technologies, as well as the reduction in the costs of these techniques, have revolutionized the understanding of the identification of metabolic pathways in plants. The mechanism by which ...

Pathophysiological mechanisms of asthma

Furthermore, there are domains of risk, which also need to be considered in any discussion of pathophysiology: Risk of acute asthma attacks, which may be fatal Risk of impaired trajectories of lung growth, which may sometimes but not inevitably be ...

agrobacterium : nature’s genetic engineer

This was followed by the discovery that a piece of the plasmid was transferred and randomly integrated into the chromosome of the plant cell. An understanding of the basic biology of this unique system made possible the development of Agrobacterium ...

Rare genetic blood disease modeling in zebrafish

In addition, because of the complexity of human diseases and the intrinsic differences between humans and other species, it is often the case that some aspects of the model organisms physiology makes it a poor model for a specific disease, ...

Unraveling the nature of autism: finding order amid change

Our central hypothesis is that children with ASD are born with a deficit in detecting invariant structures and that differences in the ability to detect invariants might explain the heterogeneity in the ASD phenotype. It is expected that difficulties in ...

Primary metabolism in fresh fruits during storage

For controlled atmosphere storage, the atmosphere composition is strictly monitored and adjusted in gas tight rooms by control systems, whereas in MA the changes in oxygen and carbon dioxide concentrations within the package are a function of factors such as ...

Healthy aging – insights from drosophila

The extent of evolutionary conservation in both the outward signs of aging and the environmental and genetic factors that influence it, suggests that aging itself is an evolutionarily conserved process and not simply an inevitable deterioration of biological systems. Studies ...

Bullying victimization and trauma

As the DSM-5 is still the predominant disorder classification system used for research on trauma, we nevertheless discuss whether it could be a source for, or give ideas to, the development of a possible conceptual framework for an integrated understanding ...

Embodied cognition is not what you think it is

These experiments claim to show how cognition can be influenced and biased by states of the body or the environment or that abstract cognitive states are grounded in states of the body and using the former affects the latter. This, ...

Perspectives on episodic-like and episodic memory

Recently, the definition of episodic memory has been expanded by Klein by postulating that the core features of episodic memory in terms of a memory for what, happened, where and when are also shared by semantic memory and that episodic ...

Primary metabolism in avocado fruit

In the decades of the 1960s on, several studies on the role of C 7 sugars and starch during growth and development of avocado were reported. Unlike other fruit in which the balance of sugars and organic acids is determinant ...

Mindfulness training: can it create superheroes?

Whilst the study of the behaviors and attributes of heroes has undergone a renaissance in recent years, the characteristics of a superhero has remained the stuff of fiction. What could also be asked, in line with Aristotle's function argument ...

Comparative virulence and genomic analysis of streptococcus suis isolates

After accurately establishing the virulence capacity of the isolates, our second objective was to obtain the closed-whole genome of each isolate and use comparative genomic analyses to evaluate the genetic and phenotypic attributes associated with swine-virulent phenotypes to link specific ...

The heart of the alzheimer’s: a mindful view of heart disease

Thus, in this review we summarize the processes of protein folding and misfolding and present the commonalities between the pathophysiology of protein misfolding diseases in the heart and the central nervous system. Those, when activated, lead to a signal cascade ...

Advancements in stem cells treatment of skeletal muscle wasting

Unfortunately, the use of stem cell in regenerative medicine is limited by the poor engraftment and persistence of transplanted cells and the risk of neoplastic formation. Pathological conditions modify the microenvironment of stem cells preventing the activation of resident stem ...

Cutaneous malassezia: commensal, pathogen, or protector?

Functional interactions can be scenarios where the skin microbiota is a direct cause, the skin microbiota is altered by changes in the skin and hence generate a deleterious host response, exacerbating the situation, or where the microbiota is uninvolved. In ...

Algae as new kids in the beneficial plant microbiome

It is important to understand the definition of the microbiome before discussing algae as a new member of the plant microbiome, since microbe and microbiome are distinct terminologies. For instance, Chlorella species are found in the soil and on the ...

Immune privilege: the microbiome and uveitis

Thus, the level of IP for each component of the eye and the brain would match the level of IP of corresponding tissues: in the case of the eye, composed as it is of vascular and avascular connective tissues forming ...

Neuropeptide y in alcohol addiction and affective disorders

The amygdala is a central neurobiological substrate in stress- and anxiety-related behavior, as well as in modulation of alcohol intake. An infusion of NPY into the central nucleus of the amygdala in alcohol-preferring rats normalizes both anxiety behaviors and alcohol ...

Rare primary central nervous system tumors in adults: an overview

EURACAN is therefore working in close collaboration with European neuro-oncology groups, particularly: the Brain Tumor Group of the European Organization for Research and Treatment of Cancer, the European Association of Neuro-Oncology, national neuro-oncology working groups and, and with ePAGs in ...

The many faces of obesity and its influence on breast cancer risk

The complex interplay of diet and physical activity, together with the role of adipose tissue, pose challenges to our understanding of the mechanisms by which obesity confers increased breast cancer risk. The focus of this review is on the relationship ...

The turkish wireless telecommunications industry essay

By comparing the performance of this industry against that of the US on the basis of the determinants of customer satisfaction in the telecommunications industry, specific recommendations are made which can help to improve customer satisfaction standards in the Turkish ...

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